Implications of HLA sequence-based typing in transplantation
نویسندگان
چکیده
منابع مشابه
A glow of HLA typing in organ transplantation
The transplant of organs and tissues is one of the greatest curative achievements of this century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the main goal of the immune response is the MHC (major histocompatibility complex) molecules expressed on the surface of donor cells. Cell surface molecules that induce an anti...
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The occurrence of graft rejection and/or graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is largely depended on whether the re‐ cipient and the donor have matched HLA types. Under normal circumstances, the individu‐ al with completely matched HLA antigens can be the donor. However, due to the high level of HLA polymorphism, the major obstacl...
متن کاملResolution of Ambiguous HLA Genotyping in Korean by Multi-Group-Specific Sequence-Based Typing
PURPOSE To evaluate a multi-group-specific sequence-based typing (SBT) method for resolving ambiguous results from human leukocyte antigen (HLA) genotyping. MATERIALS AND METHODS A total of 50 samples that showed ambiguous genotypes for at least two HLA loci from HLA-A, -B, -C and -DRB1 by the conventional SBT assay were evaluated using a new SBT test, the AVITA plus assay. The most likely HL...
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A new human leukocyte antigen-Cw*0401 allele showed one nucleotide difference from Cw*04010101 in exon 3 at nucleotide position 561 (codon 163 ACG-->ACT) without a coding change.
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The human leukocyte antigen-A (HLA-A), -B and -DRB1 polymorphism was examined in the Portuguese population, discriminating between North, Centre and South inhabitants. All data were obtained at high-resolution level, using sequence-based typing. The most frequent allele at each locus was A* 020101 (26%), B* 440301 and B* 510101 (12% each) and DRB1* 070101 (15%). The predominant three-locus hapl...
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ژورنال
عنوان ژورنال: Journal of Postgraduate Medicine
سال: 2008
ISSN: 0022-3859
DOI: 10.4103/0022-3859.39192